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Filtered Search Results
Apexbio Technology LLC Anastrozole 120511-73-1 200mg
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Anastrozole (CAS 120511-73-1) is a selective non-steroidal aromatase inhibitor that suppresses estrogen biosynthesis by inhibiting the aromatase enzyme In in vitro assays using human placental aromatase anastrozole demonstrated an IC50 of 14 6 nM (0 0043 g/ml) Oral administration at 0 1 mg/kg completely inhibited ovulation in preclinical models and eliminated exogenous androgen-induced uterotrophic activity in juvenile rodents Additionally it has been shown to inhibit the conversion of 11-deoxycortisol to cortisol in guinea pig dog and bovine adrenal microsomes with IC50 values of 4 09 M 129 M and 11 9 M respectively Anastrozole is widely used in research to study estrogen-mediated pathways and endocrine modulation
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Medchemexpress LLC Firmonertinib (mesylate) | 2130958-55-1 | 100.0% | 664.70 | 100 MG
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Firmonertinib mesylate is an orally active, mutant-selective, and blood-brain barrier penetrant EGFR inhibitor. It inhibits EGFR active mutations as well as the T790M acquired resistant mutation. Firmonertinib mesylate has the potential for the research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation.
- Orally active
- Mutant-selective
- Blood-brain barrier penetrant EGFR inhibitor
- Inhibits EGFR active mutations
- Inhibits T790M acquired resistant mutation
- Potential for research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation
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Apexbio Technology LLC NP118809 41332-24-5 200mg
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NP118809 (CAS 41332-24-5) is a potent and selective blocker of N-type voltage-gated calcium channels exhibiting an IC50 of 0 11 M in vitro It demonstrates significant selectivity over L-type calcium channels with over 100-fold preference (L-type IC50 12 2 M) In vivo studies in rats indicate that NP118809 is orally bioavailable (mean 30%) with a Tmax of 2 3 hours and a half-life of 2 1 hours following intravenous or oral administration The compound exhibits wide tissue distribution and has been shown to produce analgesic effects in animal pain models NP118809 is useful for research into N-type calcium channel function and modulation particularly in studies of pain signaling and neuropharmacology
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000427868 CINCHONIDINE 500MG
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Aobchem AOBCHEM
5000864842 2 3-DIMETHOXY-6-FLUOROPHENYLBO
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eMolecules 1368352-40-2 | ChemScene | 5-Bromo-4-ethylpyridin-2-amine | 100mg | 784458588 | CS-0334320 | MFCD22058625 | 201.067 | C7H9BrN2
Ambeed | (R)-2-Methylpiperidine | 250mg | 714088317 | A737468 | 1722-95-8 | MFCD01862168 | 99.177 | C6H13N
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TARGETMOL CHEMICALS INC Amcinonide 200MG
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Also available in 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Amcinonide (CL-34699) is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist. Purity 99.9%
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Medchemexpress LLC Tipiracil | 183204-74-2 | 99.98% | C9H11ClN4O2 | 200 MG
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Tipiracil is a thymidine phosphorylase (TPase) inhibitor intended for research use only. It increases trifluridine exposure by inhibiting its metabolism by thymidine phosphorylase. The combination of Trifluridine and Tipiracil is a new oral treatment for metastatic colorectal cancer.
- Thymidine phosphorylase (TPase) inhibitor
- Increases trifluridine exposure
- Prevents degradation of FTD
- New oral treatment for metastatic colorectal cancer
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000369984 PRMT5-IN-31 100MG
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Apexbio Technology LLC LY2784544 1229236-86-5 200mg
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LY2784544 (CAS 1229236-86-5) is a potent and selective ATP-competitive inhibitor of JAK2 tyrosine kinase exhibiting an IC50 of 3 nM It demonstrates 8-fold and 16-fold selectivity over JAK1 and JAK3 respectively In cellular assays LY2784544 effectively inhibits STAT5 phosphorylation in Ba/F3-TEL-JAK2 cells (IC50 0 191 nM) while displaying substantially reduced activity against JAK1 and JAK3-dependent STAT5 phosphorylation The compound suppresses proliferation and induces apoptosis in cells harboring the JAK2 V617F mutation In murine models it reduces tumor burden and strongly inhibits STAT5 phosphorylation in JAK2 V617F-driven cells LY2784544 is a valuable tool for studying JAK2-mediated signaling and myeloproliferative neoplasms
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Apexbio Technology LLC TAK-901 934541-31-8 200mg
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TAK-901 (CAS 934541-31-8) is a small-molecule inhibitor primarily targeting Aurora B kinase with reported IC50 values of 0 0017 M for Aurora-B/INCENP and 0 021 M for Aurora-A/TPX2 Derived from an azacarboline kinase hinge-binding chemotype TAK-901 demonstrates time-dependent selective inhibition of Aurora B suppressing histone H3 phosphorylation and inducing polyploidy in vitro It inhibits proliferation across a range of human cancer cell lines (40 500 nM) and additionally targets kinases such as FLT3 and FGFR2 in cells In preclinical rodent xenograft models TAK-901 reduces tumor growth and induces complete regression in ovarian cancer models A phase I clinical trial has evaluated its dosing and pharmacokinetic characteristics in patients with advanced solid tumors and lymphomas
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000370945 RIMEGEPANT 200MG
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Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.9% | 750.70 | 50 MG
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Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, binding to the D2 dopamine receptor with a pKi of 8.05. It is permeable to the blood-brain barrier. It stimulates [35S]-GTPγS binding at D2 dopamine receptors and acts as a strong inhibitor of brain nitric oxide synthase (neuronal NOS) and a potent inhibitor of CYP3A4.
- Potent dopamine D2/D3 receptor agonist
- Permeable to the blood-brain barrier
- Stimulates [35S]-GTPγS binding at D2 dopamine receptors
- Strong inhibitor of brain nitric oxide synthase (neuronal NOS)
- Potent inhibitor of CYP3A4
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Apexbio Technology LLC WYE-125132 (WYE-132) 1144068-46-1 200mg
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WYE-125132 (WYE-132) [CAS 1144068-46-1] is a potent ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) displaying high selectivity over PI3K isoforms It effectively targets both mTORC1 and mTORC2 complexes as demonstrated by inhibition of S6K (T389) and AKT (S473) phosphorylation in immunocomplex assays with an IC50 of 0 19 0 07 nM WYE-125132 suppresses phospho-S6K and phospho-AKT in IGF-I stimulated or mutant cell lines at low nanomolar EC50 values and inhibits proliferation across multiple cancer cell models The compound is widely utilized in research to study mTOR signaling and its role in cellular proliferation and protein synthesis
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Apexbio Technology LLC PIK-294 900185-02-6 200mg
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PIK-294 (CAS 900185-02-6) is a potent and highly selective inhibitor of the class I phosphoinositide 3-kinase (PI3K) isoform p110 with an IC50 of 10 nM It exhibits substantially reduced activity against PI3K PI3K and PI3K demonstrating a 1 000-fold 49-fold and 16-fold lower potency respectively Biochemical studies indicate that PIK-294 interacts with a high-affinity pocket in the ATP-binding site contributing to its inhibitory properties in vitro Used as a chemical probe PIK-294 aids in delineating isoform-specific PI3K functions such as the distinct roles of PI3K isoforms in insulin signaling and cellular differentiation pathways No clinical studies have been reported
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